Seventy-five years after the Economic Commission for Latin America and the Caribbean (ECLAC) was founded, reducing the concentration of income and wealth remains one of the key challenges in Latin America. This article firstly reviews the contributions made by ECLAC and Latin American structuralism to the analysis and measurement of the income distribution. It then describes the main trends of inequality in the region from 1990 to the present, and suggests items to be included on the agenda of inequality reduction in the coming years.