This document describes and analyzes implementation of eHealth in several European countries, as well as strengths and weaknesses, using this experience in order to support the management and execution of this kind of projects in other scenarios. Five EU member States evidencing different degrees of advancement in their national eHealth projects have been selected for this purpose: Belgium, Denmark, Spain, the United Kingdom and Sweden. In addition to these five cases, a brief study has been made of several international collaboration projects for the implementation of cross-border spaces for eHealth that most of these countries are currently participating in.