People of African descent suffer high levels of inequality and deprivation which, as the figures presented in this report show, have been exacerbated during the COVID-19 pandemic. This publication seeks to capture the perspectives of people of African descent and document some of their contributions and strategies for addressing the socio-health and economic crisis. To this end, the United Nations prioritizes the integration of a human rights approach in all responses to the pandemic and offers recommendations to combat structural racial discrimination and promote reconstruction with equality.