This FAL Bulletin continues the Reflections on Disruptive Technologies in Transport that ECLAC has been publishing through this medium. This edition analyses the advantages and challenges of autonomous-vehicle introduction in freight logistics and the opportunity that this represents for reducing polluting emissions associated with transport. The document also highlights the particular challenges for Latin America, where there are still significant gaps in road and digital infrastructure, in addition to a fleet of cargo vehicles more than 15 years old, which complicates new-technology regulatory and investment challenges.