This article reviews the trend of investment in Chile and its relationship with economic growth since the 1973 coup d’état; and it documents how investment remains the main growth driver. Notwithstanding that fact, innovation helps to mitigate diminishing returns from natural resources, while technology-intensive investment, such as broadband infrastructure, helps to diversify the production matrix. The article shows how a persistent increase in the investment ratio in 1990–1998 supported GDP growth of 7.1% per year; but since 1999 investment has wavered, and average growth dropped to below 4%. The article examines the macroeconomic environment and its real instability since 1999, along with investment in infrastructure, the quality of natural resources and environmental services; and it identifies challenges for boosting both investment and innovation, diversifying the production matrix and its agents, and moving towards inclusive growth.