The opportunities for innovation that arise from natural-resource production are associated with the formation of knowledge networks that facilitate learning both within and outside the sectors in question. This article identifies the types of knowledge networks associated with innovation activities in the natural-resource domain using four case studies from the region: the livestock sector in Argentina, the mining sector in Chile, agriculture in Paraguay and forestry in Uruguay. The results show that, in all four cases, natural-resource producers form networks in which scientific knowledge is exchanged. While these have heterogeneous characteristics in terms of the capabilities of the participants, their structure and degree of openness, all display potential to disseminate and create knowledge.