This guide offers a practical and conceptual road map for strengthening monitoring and evaluation systems in Latin America and the Caribbean. These systems can then be used to improve public management and promote the creation of public value. It outlines an integrated approach based on the principles of open government (transparency, participation and collaboration) and results-based management for dealing with the region’s structural challenges and bolstering its presently low levels of institutional capacity. The eight stages in this road map provide governments and their institutions with a pathway to follow in designing, implementing and advancing the sustainability of systems for evaluating the performance of public policies, programmes and projects. The guide covers technical tools, evaluation criteria, mixed methodologies and cross-cutting approaches encompassing the areas of gender mainstreaming, territorial considerations and climate change adaptation. It also underscores the importance of the institutional framework, a culture of evaluation, the effective use of information and citizen participation. This step-by-step, contextualized approach offers a way to strengthen State capacity, spur organizational learning and consolidate a more effective, transparent and people-centred form of public management.