This article concerns Mexico's industrial policy and economic performance, focusing on an analysis of the structural changes associated with NAFTA that have occurred in the country's manufacturing sector. The purpose of the article is to improve our understanding of why the post-NAFTA evolution of the Mexican economy has been characterized by lights and shadows, with low inflation, low budget deficit and a surge in non-oil exports, and on the other hand a slower than expected expansion of economic activity and employment. The article also presents some implications of economic policy that are essential for formulating a new development agenda in Mexico by which the country can finally succeed in its endeavour to attain high and sustained economic growth.