This paper analyses the 2030 Agenda for Sustainable Development and its Sustainable Development Goals in light of the challenges and priorities for gender equality and women’s rights and autonomy in Latin America and the Caribbean. Examples are presented to illustrate the interconnections between the goals and targets of the 2030 Agenda and to underscore the importance of taking an integrated approach in order to ensure that progress on some Sustainable Development Goals is not achieved by means that could impede the attainment of goals and targets associated with gender equality and women’s rights. This paper concludes that the Regional Gender Agenda provides a roadmap for achieving the Sustainable Development Goals in Latin America and the Caribbean through the implementation of public policies that link up the economic, social and environmental dimensions of sustainable development and contribute to the eradication of gender inequalities and inequalities within and among countries