A little more than a decade since the adoption of the 2030 Agenda for Sustainable Development, progress in the achievement of the Sustainable Development Goals (SDGs) in Latin America and the Caribbean is limited. Just 19% of SDG targets are expected to be met by 2030. In 2025 and early 2026, fulfilling the SDGs was complicated further by a new era of uncertainty and geopolitical fragmentation. The world is facing major disruptions: increasing protectionism, greater competition for industrial and technological supremacy, and weaker collaboration in trade, investment, access to technology and financial support for development. Countries must become more pragmatic in this new era. They must ensure greater coordination between government, the private sector, civil society, academia and other stakeholders, and strengthen their institutional and domestic resource mobilization capacities in order to step up implementation of the measures needed to achieve the SDGs.