In this tenth edition of “The Outlook for Agriculture and Rural Development in the Americas: A Perspective on Latin America and the Caribbean”, we underscore the key importance of regional cooperation in addressing the challenges and opportunities resulting from converging crises. Within this context, strengthening regional cooperation not only fosters more sustainable, inclusive and resilient agrifood systems, but also bolsters collaborative actions in areas in which collective action, both at the national level and between countries, is the only way to make a significant difference.