This FAL Bulletin presents opportunities for physical river integration in South America that could mark an important step in the design of a sustainable river navigation system for the region. It also examines the opportunities that intermodal transport offers for regional logistics. This document is part of ECLAC analyses on infrastructure and connectivity. The study was carried out with the support of the regular programme of technical cooperation of ECLAC, in the framework of the activities of the United Nations Development Account project entitled “Transport and trade connectivity in the age of pandemics: contactless, seamless and collaborative United Nations solutions”