E-commerce fosters innovation and contributes to the process of digital transformation of MSMEs through the implementation of digital technologies, new business practices and new business models, which can improve the efficiency and productivity of companies beyond the effects on access to new national and international markets. This document presents some practices and policies that governments in Latin American and Caribbean countries have implemented before and after the COVID-19 pandemic to promote the participation of MSEs in cross-border e-commerce, including measures to deepen the penetration of the Internet, as well as encourage the adoption of technology-based business models.