In its 2021 edition, this ECLAC annual report examines the foreign trade performance of the region’s economies during the current year, with the most recent figures available on the impact of COVID-19 and the post-pandemic recovery in the distinct countries. The publication consists of three chapters. The first analyzes the evolution of global and regional trade in the last year and their prospects for a post-pandemic recovery. The second chapter examines the challenge of achieving productive autonomy in the region’s health industry, and the third offers proposals for defining the contribution of international trade to the new circular economy.