Applying data envelopment analysis (DEA) to data from the 2016 Global Innovation Index (GII) (Cornell University/INSEAD/WIPO, 2016), the paper evaluates the efficiency of 19 Latin American and Caribbean economies in creating innovation-friendly environments. Where the region performs best is on infrastructure and adaptation of information and communication technologies (ICTs), but there are problems with human capital formation, the conduct and impact of research, and institutional aspects. The output of countries such as Chile and Colombia proved lower than expected given their factors, meaning that their strong innovation results are not matched by their efficiency management. Enhancing market functioning (competition, credit and investment) and knowledge absorption capacities is among the main challenges for the region.