This paper analyses the role that Multilateral Development Banks (MDBs) have played in financing development in Latin America and the Caribbean (LAC) and what their role will be in support of the Sustainable Development Goals (SDGs). In a context where multilateralism is severely questioned, donor countries are moving their resources away from middle-income countries, and MDBs' lending represents a decreasing share of total debt in the region, we show that there is room for MDBs to continue being relevant players.